Immunoglobulin heavy chain variable gene usage and (super)-antigen drive in chronic lymphocytic leukemia.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 20068107.
- Also identified by DOI 10.1158/1078-0432.CCR-09-2948.
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Abstract
Increasing evidence supports the prognostic relevance of specific immunoglobulin heavy chain variable (IGHV) genes or stereotyped B-cell receptors (BCR) in chronic lymphocytic leukemia (CLL). The clonotypic BCRs differ in their specificity and affinity toward classical antigens and/or superantigens. The BCR-triggered mechanisms are distinct but could explain in part the different clinical behavior among CLL subgroups.
Medical subject headings
- Gene Rearrangement
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Leukemia, Lymphocytic, Chronic, B-Cell
- Superantigens