Aire, master of many trades.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20085700.
- Also identified by DOI 10.1016/j.cell.2009.12.036.
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Abstract
In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available for the induction of central T cell tolerance. By analyzing Aire's interacting partners, Abramson et al. (2010) shed new light on this unorthodox form of gene expression.
Medical subject headings
- Autoantigens
- Gene Expression Regulation
- Immune Tolerance
- Thymus Gland
- Transcription Factors