Chewing the fat on tumor cell metabolism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20085702.
- Also identified by DOI 10.1016/j.cell.2009.12.037.
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Abstract
Tumor cells undergo a metabolic shift toward specific bioenergetic (glycolysis) and anabolic (protein and lipid synthesis) processes that promote rapid growth. Nomura et al. (2010) now demonstrate that an increase in monoacylglycerol lipase (MAGL) drives tumorigenesis through the lipolytic release and remodeling of free fatty acids.
Medical subject headings
- Lipid Metabolism
- Monoacylglycerol Lipases
- Neoplasms