Clking on PGC-1alpha to inhibit gluconeogenesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 20085730.
- Also identified by DOI 10.1016/j.cmet.2009.12.003 and PMC identifier 3616263.
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Abstract
The link between Akt activation and gluconeogenic repression remains unclear, despite many years of investigation and remarkable progress. Rodgers and colleagues now introduce us to the Clk2 kinase, an Akt substrate that can directly phosphorylate and inhibit PGC-1alpha, blunting hepatic glucose production.
Medical subject headings
- Gluconeogenesis
- Heat-Shock Proteins
- Transcription Factors