Powering reprogramming with vitamin C.
editorial · Level V
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- Record sourced from PubMed, PMID 20085733.
- Also identified by DOI 10.1016/j.stem.2009.12.012.
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Abstract
In this issue of Cell Stem Cell, Esteban et al. (2009) report that vitamin C enhances the reprogramming efficiency of mouse and human fibroblasts transduced with three (Oct4/Klf4/Sox2) or four (Oct4/Klf4/Sox2/cMyc) factors. Vitamin C can alleviate cell senescence by p53 repression and may accelerate reprogramming by synergizing with epigenetic regulators.