Fine-tuning silencing.
basic_science · Level V
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- Record sourced from PubMed, PMID 20085734.
- Also identified by DOI 10.1016/j.stem.2009.12.013 and PMC identifier 4512832.
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Abstract
Polycomb Repressive Complex 2 (PRC2) modifies chromatin to silence many embryonic patterning genes, restricting their expression to the appropriate cell populations. Two reports in Cell by Peng et al. (2009) and Shen et al. (2009) identify Jarid2/Jumonji, a new component of PRC2, which inhibits PRC2 enzymatic activity to fine-tune silencing.