TRRAP and the maintenance of stemness in gliomas.
basic_science · Level V
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- Record sourced from PubMed, PMID 20085736.
- Also identified by DOI 10.1016/j.stem.2009.12.005.
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Abstract
Resistance of brain tumors to therapy and their eventual recurrence is attributed to stem-like cells. In this issue of Cell Stem Cell, a high-throughput kinome-wide screen (Wurdak et al., 2010) has identified TRRAP, a kinase-related protein, as being required for stem cell character in gliomas.