Nonresponder patients with hepatitis C virus genotype 2/3 infection: a question of low systemic interferon concentrations?
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 20088695.
- Also identified by DOI 10.1086/650006.
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Abstract
Twelve of 303 per-protocol patients were nonresponders in a 12-week versus 24-week treatment study of hepatitis C virus (HCV) genotype 2/3 infection. The nonresponders had significantly lower interferon concentrations, as well as significantly greater mean age, body mass index, and viral load. Suboptimal drug concentrations may thus contribute to lack of response to therapy in patients with infection due to HCV genotype 2/3.
Medical subject headings
- Hepacivirus
- Hepatitis C
- Interferon-alpha
- Polyethylene Glycols