Reversible brain death. A manifestation of amitriptyline overdose.

Yang, K L; Dantzker, D R · Chest · 1991

case_report · Level V

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Abstract

Tricyclic antidepressants are known to cause central nervous system depression. However, a generalized depression of brainstem functions is rarely reported. We report a patient in deep coma with complete absence of brain-stem reflexes after she had taken a large quantity of amitriptyline. With continuous supportive treatment, she eventually regained all neurologic function and made a full recovery.

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