The role of genetic diversity in cancer.
Level V
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- Record sourced from PubMed, PMID 20101092.
- Also identified by DOI 10.1172/JCI42088 and PMC identifier 2810093.
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Abstract
The role of genetic heterogeneity within neoplasms is increasingly recognized as important for understanding the dynamics of cancer progression, cancer stem cells, and therapeutic resistance, and there is interest in intratumoral heterogeneity measurements as potential biomarkers for risk stratification. In this issue of the JCI, Park et al. characterize this genetic diversity in carcinoma in situ and in invasive regions from 3 types of human breast cancers and lay the groundwork for translation of these measures to the clinic.
Medical subject headings
- Genetic Variation
- Neoplasms