Fifteen-piconewton force detection from neural growth cones using nanowire arrays.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20102185.
- Also identified by DOI 10.1021/nl902675h.
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Abstract
We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mum. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy. Forces down to 15 pN were measured on neural growth cones, showing that this method can be used to study the fine details of growth-cone dynamics.
Medical subject headings
- Growth Cones
- Microarray Analysis
- Nanotechnology
- Nanotubes
- Transducers