Vaccine-acquired rotavirus in infants with severe combined immunodeficiency.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 20107217.
- Also identified by DOI 10.1056/NEJMoa0904485 and PMC identifier 4103739.
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Abstract
Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.
Medical subject headings
- Rotavirus
- Rotavirus Infections
- Rotavirus Vaccines
- Severe Combined Immunodeficiency