Towards building a chromosome segregation machine.
basic_science · Level V
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- Record sourced from PubMed, PMID 20110988.
- Also identified by DOI 10.1038/nature08912 and PMC identifier PMC2753282.
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Abstract
All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 x 10(9) base pairs) of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell. The strategy by which DNA is replicated is now well understood. But when it comes to packaging and segregating a genome, the mechanisms are only beginning to be understood and are often as variable as the organisms in which they are studied.