Effect of long-term L-dopa administration on striatal extracellular dopamine release.
basic_science · Level V
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Abstract
When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.
Medical subject headings
- Corpus Striatum
- Dopamine
- Extracellular Space
- Levodopa