Host-guest interaction mediated polymeric assemblies: multifunctional nanoparticles for drug and gene delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20112968.
- Also identified by DOI 10.1021/nn901213a and PMC identifier 2835570.
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Abstract
Novel core-shell structured nanoassemblies are assembled by a beta-cyclodextrin containing a positively charged host polymer and a hydrophobic guest polymer. The hydrophobic core of these types of assemblies serves as a nanocontainer to load and release the hydrophobic drugs, while the positively charged hydrophilic shell is able to condense the plasmid DNA and achieve its transfection/expression in osteoblast cells. These assemblies may be used as a new generation of multifunctional nanocarriers for simultaneous drug delivery and gene therapy.
Medical subject headings
- Drug Carriers
- Gene Transfer Techniques
- Nanoparticles
- Polymers