Excessive activation of the complement system in atypical hemolytic uremic syndrome: is it ready for prime time?
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 20118898.
- Also identified by DOI 10.1038/ki.2009.467 and PMC identifier 3153079.
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Abstract
Complement factor I (CFI) mutations are implicated in the pathogenesis of atypical hemolytic uremic syndrome (aHUS). Nevertheless, there is evidence that CFI deficiency is a weak effector of aHUS. Bienaime et al. report that homozygous deletion of CFHR-1 in the RCA gene cluster of chromosome 1q is a major risk factor for poor outcome for patients with CFI mutations. The basic and clinical implications of the findings are further elaborated here.
Medical subject headings
- Complement Activation
- Hemolytic-Uremic Syndrome