Continuous infusion of amphotericin B deoxycholate in the treatment of cryptococcal meningoencephalitis: analysis of safety and fungicidal activity.
case_series · Level IV
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- Record sourced from PubMed, PMID 20121575.
- Also identified by DOI 10.1086/650489.
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Abstract
We measured fungicidal activity of continuous infusion of amphotericin B deoxycholate plus 5'flucytosine using quantitative cultures of cerebrospinal fluid (CSF) obtained from lumbar punctures of human immunodeficiency virus (HIV)-infected patients with neurocryptococcosis during 14 days of treatment. Glomerular renal function was preserved in all patients. Mycological efficacy with progressive reduction in CSF cryptococcal colony-forming units was comparable to standard 4-h infusion of amphotericin B.
Medical subject headings
- Amphotericin B
- Antifungal Agents
- Deoxycholic Acid
- Meningitis, Cryptococcal