Bone diseases: Interferon regulatory factor-8 suppresses osteoclastogenesis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 20125173.
- Also identified by DOI 10.1038/nrrheum.2009.274.
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Abstract
To date, understanding of the molecular mechanisms of bone metabolism has centered on three tumor necrosis factor family members--RANK, its ligand RANKL and its decoy receptor osteoprotegrin. This view should now be modified, however, to incorporate the role of interferon regulatory factor-8.
Medical subject headings
- Interferon Regulatory Factors
- Osteoclasts
- Osteoporosis