Blocking the deadly effects of the NMDA receptor in stroke.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 20141829.
- Also identified by DOI 10.1016/j.cell.2010.01.014.
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Abstract
Excessive activation of NMDA glutamate receptors contributes to neuronal death after stroke. In this issue, Tu et al. (2010) demonstrate that ischemic injury promotes the association of death-associated protein kinase 1 with the NMDA receptor, thereby potentiating its activity, and show that disrupting this association reduces damage to the brain.
Medical subject headings
- Apoptosis Regulatory Proteins
- Calcium-Calmodulin-Dependent Protein Kinases
- Receptors, N-Methyl-D-Aspartate
- Stroke