USP10: friend and foe.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 20144755.
- Also identified by DOI 10.1016/j.cell.2010.01.034.
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Abstract
The tumor suppressor protein p53, a crucial player in the DNA damage response, is regulated in many ways, most notably through ubiquitination. In this issue, Yuan et al. (2010) identify the deubiquitinating protease USP10 as a new regulator of p53 in the DNA damage response and tumor development.
Medical subject headings
- DNA Repair
- Ubiquitin Thiolesterase