Fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation in an adolescent.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 20156061.
- Also identified by DOI 10.1086/650007.
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Abstract
We describe a unique case of fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation presenting in an adolescent. Detailed assays of Epstein-Barr virus-specific T cell immunity revealed defects in the patient's T cell receptor signalling pathway characterized by a lack of interleukin-2 and CD25 expression, which may have contributed to her clinical course. Allogeneic stem cell transplantation reversed the clinical and laboratory phenotype.
Medical subject headings
- Herpesvirus 4, Human
- Infectious Mononucleosis
- Virus Activation