Distinguishing the viability of a single yeast cell with an ultra-sensitive radio frequency sensor.

Yang, Yang; Zhang, Hanqiao; Zhu, Junjie; Wang, Gaoyan; Tzeng, Tzuen-Rong; Xuan, Xiangchun; Huang, Kama; Wang, Pingshan · Lab Chip · 2010

basic_science · Level V

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Abstract

We propose and demonstrate a simple, ultra sensitive radio frequency (RF) sensor to detect a single yeast cell and distinguish its viability in a microfluidic channel. On-chip interference is used to cancel background probing signals to improve sensor sensitivity. Individual viable and nonviable yeast cells (approximately 5.83 +/- 0.85 microm in diameter) are measured with clear sensing and identification of these cells.

Medical subject headings