Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20163184.
- Also identified by DOI 10.1021/nl1002526 and PMC identifier 3988696.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Multivalent nanoparticle platforms are attractive for biomedical applications because of their improved target specificity, sensitivity, and solubility. However, their controlled assembly remains a considerable challenge. An efficient hydrazone ligation chemistry was applied to the assembly of Cowpea mosaic virus (CPMV) nanoparticles with individually tunable levels of a VEGFR-1 ligand and a fluorescent PEGylated peptide. The nanoparticles recognized VEGFR-1 on endothelial cell lines and VEGFR1-expressing tumor xenografts in mice, validating targeted CPMV as a nanoparticle platform in vivo.
Medical subject headings
- Drug Delivery Systems
- Hydrazones
- Image Enhancement
- Nanostructures
- Virion