Elevated serum IL-8 levels in ataxia telangiectasia.

McGrath-Morrow, Sharon A; Collaco, J Michael; Crawford, Thomas O; Carson, Kathryn A; Lefton-Greif, Maureen A; Zeitlin, Pamela; Lederman, Howard M · J Pediatr · 2010

cross_sectional · Level IV

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Abstract

Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <.0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

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