Caffeine increases cerebral cortical activity in preterm infants.

Supcun, Sirma; Kutz, Patrizia; Pielemeier, Wolfgang; Roll, Claudia · J Pediatr · 2010

case_series · Level IV

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Abstract

Caffeine improves the rate of survival without neurodevelopmental disability in preterm infants. The mechanisms underlying neuroprotection are incompletely understood. In 51 preterm infants studied by amplitude-integrated electroencephalography from 2 hours before to 2 hours after intravenous caffeine administration, we found that caffeine increases amplitudes and periods of continuity.

Medical subject headings