IgE, mast cells, basophils, and eosinophils.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20176269.
- Also identified by DOI 10.1016/j.jaci.2009.11.017 and PMC identifier 2847274.
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Abstract
IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcepsilonRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis.
Medical subject headings
- Basophils
- Eosinophils
- Hypersensitivity, Immediate
- Immunoglobulin E
- Mast Cells