Reining in H(2)O(2) for safe signaling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20178737.
- Also identified by DOI 10.1016/j.cell.2010.02.003.
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Abstract
Mammalian cells use hydrogen peroxide (H(2)O(2)) not only to kill invading pathogens, but also as a signaling modulator. Woo et al. (2010) now show that the local inactivation of a H(2)O(2)-degrading enzyme ensures that the production of this oxidant is restricted to the signaling site.
Medical subject headings
- Hydrogen Peroxide
- Signal Transduction