Serological evidence of human hantavirus infections in Guinea, West Africa.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 20187741.
- Also identified by DOI 10.1086/651169.
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Abstract
We recently discovered a novel hantavirus, Sangassou virus, in Guinea, West Africa. Using enzyme-linked immunosorbent assays followed by confirmatory and serotyping assays, we retrospectively detected hantavirus antibodies in 3 (4.4%) of 68 patients with fever of unknown origin in Sangassou village, Forest Guinea. A population-based survey in Forest Guinea (n = 649) found the prevalence of hantavirus antibodies to be 1.2%. Specific neutralizing antibodies against Sangassou virus were demonstrated in serum samples from 2 patients and in 2 serum samples of the serosurvey. Our data allow us to conclude that hantavirus infections may be a significant unrecognized medical problem in at least this part of Africa.
Medical subject headings
- Antibodies, Viral
- Orthohantavirus
- Hantavirus Infections