The FOX(O1) blasts off.
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- Record sourced from PubMed, PMID 20197048.
- Also identified by DOI 10.1016/j.cmet.2010.02.009.
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Abstract
Systemic glucose homeostasis is primarily regulated by insulin, which targets liver, fat, and skeletal muscle cells, setting up important feedback loops. New studies now show that the osteoblast also has a significant role in modulating systemic insulin responses, via the insulin-regulated transcription factor FOXO1 and the hormone osteocalcin.