Peptides signal mitochondrial stress.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20197049.
- Also identified by DOI 10.1016/j.cmet.2010.02.011.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The unfolded protein response (UPR(mt)) rebalances mitochondrial protein homeostasis upon proteotoxic perturbations. Haynes et al. (2010) show that this retrograde stress signal is based on efflux of peptides derived from damaged proteins from the mitochondrial matrix to the cytosol; this initiates downstream protective responses in the nucleus to restore cellular balance.