Microbial translocation correlates with the severity of both HIV-1 and HIV-2 infections.
Where this comes from
- Record sourced from PubMed, PMID 20199244.
- Also identified by DOI 10.1086/651430.
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Abstract
Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4+ T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4+ T cells, increase in viral load, and defective immune stimuli responsiveness during both HIV type 1 and HIV type 2 infections.
Medical subject headings
- Bacterial Translocation
- HIV Infections
- HIV-1
- HIV-2