PARP inhibition: PARP1 and beyond.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20200537.
- Also identified by DOI 10.1038/nrc2812 and PMC identifier 2910902.
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Abstract
Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.
Medical subject headings
- Poly(ADP-ribose) Polymerases