The use of fluorocarbon emulsions in cancer radiotherapy.
review · Level V
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Abstract
The chemical and physical properties of perfluorochemical emulsions which highlight their advantages and disadvantages for use in cancer radiotherapy are summarized. The radiobiological properties of two emulsions are reviewed: we have chosen the Fluosol-DA 20% and the PFOB emulsion 100 v/w% which is one of the most promising second generation fluorocarbon emulsions. The radiosensitization obtained in a human tumor xenograft with PFOB emulsion is compared to that obtained with other modalities used to overcome the radioresistance of tumour cells linked to hypoxia.
Medical subject headings
- Blood Substitutes
- Fluorocarbons
- Neoplasms
- Plasma Substitutes
- Radiation-Sensitizing Agents