Membrane curvature in synaptic vesicle fusion and beyond.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20211126.
- Also identified by DOI 10.1016/j.cell.2010.02.017.
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Abstract
Recent evidence suggests that the Ca(2+)-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.
Medical subject headings
- Cell Membrane
- Intracellular Membranes
- Synaptic Vesicles