Preview. MicroRNAs: from decay to decoy.
editorial · Level V
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- Record sourced from PubMed, PMID 20211130.
- Also identified by DOI 10.1016/j.cell.2010.02.020.
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Abstract
MicroRNAs interact with Argonaute proteins to guide posttranscriptional gene silencing. Eiring et al. (2010) now show that miR-328 has a second function, acting as a decoy by binding to hnRNP E2 and lifting its translational repression of an mRNA involved in myeloid cell differentiation.