Evaluation of the biocompatibility of novel peptide hydrogel in rabbit eye.
basic_science · Level V
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- Record sourced from PubMed, PMID 20225215.
- Also identified by DOI 10.1002/jbm.b.31562.
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Abstract
A peptide containing a RGD (arginine-glycine-aspartic acid) sequence as well as a hydrophobic N-fluorenyl-9-methoxycarbonyl (FMOC) tail was prepared via a standard FMOC solid-phase peptide synthesis technique. The supramolecular self-assembly of such peptide through pi-pi stacking from FMOC tail can transfer the peptide aqueous solution into a three-dimensional hydrogel. The biocompatibility of the peptide hydrogel was evaluated via clinical follow-up and histological analysis. The data obtained demonstrated that the peptide hydrogel exhibited good biocompatibility when injected to the subconjunctival space and anterior chamber of rabbit, indicating a potential application in ophthalmology as an implantable drug delivery system for the treatment to ocular anterior segment diseases such as glaucoma, iridocyclitis, and keratopathy.
Medical subject headings
- Eye
- Hydrogels
- Infusion Pumps, Implantable
- Materials Testing
- Oligopeptides