In vivo wide-area cellular imaging by side-view endomicroscopy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20228814.
- Also identified by DOI 10.1038/nmeth.1440 and PMC identifier 2849759.
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Abstract
In vivo imaging of small animals offers several possibilities for studying normal and disease biology, but visualizing organs with single-cell resolution is challenging. We describe rotational side-view confocal endomicroscopy, which enables cellular imaging of gastrointestinal and respiratory tracts in mice and may be extensible to imaging organ parenchyma such as cerebral cortex. We monitored cell infiltration, vascular changes and tumor progression during inflammation and tumorigenesis in colon over several months.
Medical subject headings
- Diagnostic Imaging
- Endoscopy, Gastrointestinal
- Microscopy, Confocal