Covalently linked DNA nanotubes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20235526.
- Also identified by DOI 10.1021/nl100389v.
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Abstract
The present study introduces an approach to prepare covalently linked DNA nanotubes. A circular DNA that includes at its opposite poles thiol and amine functionalities acts as the building block for the construction of the DNA nanotubes. The circular DNA is cross-linked with a bis-amide-modified nucleic acid to yield DNA nanowires, and these are subsequently cross-linked by a bis-thiolated nucleic acid to yield the DNA nanotubes. Alternatively, a circular DNA that includes four amine functionalities on its poles is cross-linked in one-step by the bis-thiolated nucleic acid to yield the nanotubes. The resulting nanostructures are stable and nonseparable upon heating.
Medical subject headings
- DNA, Circular
- Nanotubes