Acute lymphoblastic leukemia with t(4;11) translocation after osteogenic sarcoma.
case_report · Level V
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Abstract
The authors report a case of acute lymphoblastic leukemia (ALL) with t(4;11) (q21;q23) occurring 9 months after treatment of osteogenic sarcoma. Cell surface marker and molecular analyses suggest early B lineage involvement. This is the first report, to the knowledge of the authors, of t(4;11) ALL arising after an osteogenic sarcoma. The observations of the authors support the possibility of a causal relationship between exposure to carcinogens and the occurrence of leukemia with t(4;11).
Medical subject headings
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 4
- Neoplasms, Multiple Primary
- Osteosarcoma
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Tibia
- Translocation, Genetic