Interactions between calcium channel blockers and the anticonvulsants carbamazepine and phenytoin.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 2027492.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We describe a retrospective analysis of the frequency of adverse interactions between calcium channel blockers and anticonvulsant drugs (phenytoin and carbamazepine) in a series of 43 patients. Ten patients receiving carbamazepine and three patients receiving phenytoin exhibited symptoms or signs of toxicity. Toxicity occurred with both diltiazem and verapamil, but not with nifedipine. These results emphasize the need for careful clinical and laboratory monitoring of patients receiving both classes of medication.
Medical subject headings
- Angina Pectoris
- Calcium Channel Blockers
- Carbamazepine
- Phenytoin
- Seizures