Immunity, inflammation, and cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20303878.
- Also identified by DOI 10.1016/j.cell.2010.01.025 and PMC identifier 2866629.
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Abstract
Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention.
Medical subject headings
- Inflammation
- Neoplasms