Direct determination of molecular haplotypes by chromosome microdissection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20305652.
- Also identified by DOI 10.1038/nmeth.1443 and PMC identifier 2871314.
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Abstract
Direct observation of haplotypes is still technically challenging. Here we report a method for the determination of haplotypes through chromosome microdissection. We determined human long-range chromosomal haplotypes with more than 98.85% accuracy at 24,245 genome-wide heterozygous single-nucleotide polymorphism (SNP) loci.
Medical subject headings
- Chromosome Mapping
- Genome, Human
- Haplotypes
- Microdissection