Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 20345239.
- Also identified by DOI 10.1086/651605 and PMC identifier 2946636.
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Abstract
Pandemic 2009 H1N1 virus isolates containing the neuraminidase inhibitor resistance mutation H275Y have been reported. We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of clinically significant resistance to peramivir.
Medical subject headings
- Antiviral Agents
- Cyclopentanes
- Drug Resistance, Viral
- Guanidines
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
- Oseltamivir