Neoadjuvant temsirolimus effectiveness in downstaging advanced non-clear cell renal cell carcinoma.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 20347211.
- Also identified by DOI 10.1016/j.eururo.2010.03.005.
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Abstract
A 35-year-old woman presented with a 12-cm right renal mass with retroperitoneal lymph node involvement and pulmonary and bone metastases. Renal mass biopsy revealed an unclassified high-grade non-clear cell renal cell carcinoma (RCC) with eosinophilic cells. Due to the extent of the disease, neoadjuvant temsirolimus was initiated. After 6 wk of treatment, a significant downstaging of the disease and complete disappearance of the metastases were noticed on computed tomography scan. Three months later, a laparoscopic radical nephrectomy and lymphadenectomy was performed. Final pathology confirmed a high-grade non-clear cell RCC, with necrotic changes on lymph node specimens, pT1bN0Mx.
Medical subject headings
- Antineoplastic Agents
- Carcinoma, Renal Cell
- Kidney Neoplasms
- Sirolimus