More night than day--circadian rhythms in polymyalgia rheumatica and ankylosing spondylitis.
review · Level V
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- Record sourced from PubMed, PMID 20360185.
- Also identified by DOI 10.3899/jrheum.091283.
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Abstract
The circadian rhythm of symptoms in patients with chronic inflammatory diseases is well known. Circadian rhythms could be used to identify targets for time-adapted antiinflammatory therapies, which are administered prior to the flare of cytokine synthesis and inflammatory activity. In recent years, the diurnal variations in rheumatoid arthritis have been described precisely for pain, stiffness, and functional disability, as well as the underlying cyclic variations in hormone levels and cytokine concentrations. This review summarizes the current knowledge on circadian rhythms in other rheumatic diseases, focusing on polymyalgia rheumatica and ankylosing spondylitis.
Medical subject headings
- Circadian Rhythm
- Polymyalgia Rheumatica
- Spondylitis, Ankylosing