The hair follicle bulge stem cell niche resists transformation by the hedgehog pathway.
review · Level V
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- Record sourced from PubMed, PMID 20362530.
- Also identified by DOI 10.1016/j.stem.2010.03.009 and PMC identifier 3689650.
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Abstract
Similarities between basal cell carcinoma (BCC) tumor cells and hair follicle keratinocytes had previously suggested that BCC originates within the hair follicle bulge stem cell niche. However, in the current Nature Cell Biology, Youssef et al. (2010) show that BCC instead originates in the interfollicular epidermis.