Researching genetic versus nongenetic determinants of disease: a comparison and proposed unification.

Ioannidis, John P A; Loy, En Yun; Poulton, Richie; Chia, Kee Seng · Sci Transl Med · 2009

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Abstract

Research standards deviate in genetic versus nongenetic epidemiology. Besides some immutable differences, such as the correlation pattern between variables, these divergent research standards can converge considerably. Current research designs that dissociate genetic and nongenetic measurements are reaching their limits. Studies are needed that massively measure genotypes, nongenetic exposures, and outcomes concurrently.

Medical subject headings