Fingered for a fat fate.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20374953.
- Also identified by DOI 10.1016/j.cmet.2010.02.014.
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Abstract
Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage. A recent report (Gupta et al., 2010) identifies the zinc finger protein Zfp423 as a determining factor in preadipocyte commitment.
Medical subject headings
- Adipocytes
- Cell Differentiation
- DNA-Binding Proteins
- Mesenchymal Stem Cells
- Models, Biological
- PPAR gamma
- Transcription Factors