Phosphatase 2A puts the brakes on mTORC1 nutrient signaling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20374954.
- Also identified by DOI 10.1016/j.cmet.2010.03.011.
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Abstract
Nutrients such as amino acids (aa) and glucose mediate mammalian target of rapamycin complex 1 (mTORC1) signaling to control cell growth and metabolism. Recent studies (Yan et al., 2010) identify a contributor, PP2A phosphatase subunit PR61varepsilon, in regulating the aa-sensitive input to mTORC1.
Medical subject headings
- Nutritional Physiological Phenomena
- Obesity
- Phosphatidylinositol 3-Kinases
- Protein Phosphatase 2
- Signal Transduction
- Transcription Factors