Endoplasmic reticulum stress and atherosclerosis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20376052.
- Also identified by DOI 10.1038/nm0410-396 and PMC identifier 2897068.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are strongly influenced by pathways that lie at the interface of chronic inflammation and nutrient metabolism. Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications.
Medical subject headings
- Atherosclerosis
- Endoplasmic Reticulum
- Stress, Physiological